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Symptoms caused by hyposerotonergic (low serotonin) conditions may mimic migraine headache symptoms. The artificial or fake serotonin, known as agonists, found in many migraine drugs do nothing to increase serotonin concentrations to levels required for control of symptoms caused by hyposerotonergic conditions.

When hyposerotonergic conditions exist, these medical foods provide the body with the nutrition intake required to synthesize serotonin concentration higher than is possible with optimal modification of the normal diet.

Hyposerotonergic Migraine Medical Foods


“B1” = Bottle #1 HMMF

“B2” = Bottle #2 HMMF

Hyposerotonergic condition symptoms associated with migraine.

All adults (16 years and older) need to take
vitamin B6 100mg, two pills perday (not B-complex) in addition to the following.

AM Noon 4 pm
Level 1: Day 0 3 pills 🠆 “B1” 3 pills 🠆 “B1”
Level 2: Day 7 3 pills 🠆 “B1” 3 pills 🠆 “B1” 2 pills 🠆 “B2”
Level 3: Day 14 3 pills 🠆 “B1” 3 pills 🠆 “B1” 4 pills 🠆 “B2”

It takes five days for optimal results to be observed (systemic equilibrium).

  • If symptoms are still present after seven days, increase to the next level
  • If symptoms have resolved completely after seven days on any level, do not increase to the next level.
  • Continue the medical food for six months after relief of symptoms, then stop. If symptoms return, restart the medical food.
  • If nausea develops with the first dose, take it 4 to 5 hours after waking.
  • If symptoms continue one week after starting level 3, consider other etiology.


  • Hyposerotonergic Migraine Medical Food Bottle #1 and Bottle #2
  • Vitamin B6 100 mg (not B-Complex)


“In migraine patients, more likely sensitization of some groups of 5-HT (serotonin) receptors, namely auto receptors 5-HT and 5-HT from chronic hyposerotonergic state”

Sakai, Y. et al. Cephalalgia Vol 34, Issue 3, Mar 2014, Pages 165-173

“Migraine patients have chronically low systemic 5-HT (serotonin)”

Ferrari MD, S. et al. Cephalalgia 1993, 13:151-65.

“Hyposerotonergic status may be related to central sensitization of headache.”

Paola, S. et al. J Neuro Sci Volume 198, Issues 1-2, 15 June 2022, Pages 9-15

“Migraine patients have a low cerebral serotonin level between attacks.”

Deen, M. et al. Cephalalgia Vol 37, Issue 3, Mar 2017, Pages 251-264